The problem extends from the brain to the liver, she said. Not only are the different forms of thyroid hormone low, but the genes that convert them to a form the cell can use are also out of kilter. Even the things that the thyroid hormones regulate fats and glucose are out of balance. Because Aagaard’s laboratory has not been previously involved in thyroid hormone research, they turned to other experts in the field who recommended they take an exhaustive approach to characterizing the fetal thyroid axis in their studies.
„We looked at the expression and production of Li Shou Slimming Capsules nearly all known key proteins, hormones, and receptors important in regulating thyroid hormone. We looked from the brain to the thyroid gland and all the way down to the liver. We looked deeply into the regulation of the thyroid hormone receptor as well as the effector molecules. It is a deeply perturbed axis,“ she said.
Aagaard’s laboratory is involved in identifying and studying changes that happen in the womb that can affect the risk of disease 40 years or more later.
“Changes in the thyroid axis in uteruo may make an individual more susceptible to the metabolic changes seen with obesity, diabetes or cardiovascular disease,” she said. “What is particularly interesting is that it appears that it is largely the maternal diet (and not maternal obesity per se) that most influences the fetal thyroid axis. We were particularly intrigued by the ability of the maternal diet to epigenetically program the thyroid hormone receptor beta histone code in the developing fetus.” (Histones are proteins in the cell nucleus that help package the DNA into nucleosomes and act as spools around which DNA winds.)
Others who took part in this work include Haleh Sangi-Haghpeykar, Lori Showalter, Cynthia Shope, Min Hu, Kathleen Brown, R. Alan Harris of BCM, Sarah Williams and Kevin L. Grove of the Oregon National Primate Center and Robert H. Lane of the University of Utah in Salt Lake City.
Funding for this work came from National Institutes of Health Director New Innovator Award, the National Institute of Child Health and Human Development/National Institute of Diabetes and Digestive and Kidney Diseases and the NIH Research Education and Career Horizon Institutional Research and Academic Career Development Award (REACH IRACDA).London – If you can’t stick to a diet, no matter how much you want to, your memory may be to blame.Researchers have linked a set of traits, including a form of memory, to how well slimmers stick to their intentions.
Those who fall down on the traits, known collectively as executive function, are more likely to give into temptation.
Executive function covers the ability to weigh up options, prioritise, multi-task and plan ahead. It also includes prospective memory – the form of recall that we need to carry out plans.
People with poor prospective memory forget to do things planned for the near future, such as locking the door, meeting a friend or posting a letter.
In the case of dieters, it could simply lead to them forgetting they are on a diet.
Researcher Julia Allan, a health psychologist, said: “Prospective memory keeps you on track. Every time you are offered something to eat, you have to bring to mind that you are on a diet.”
A series of studies carried out at Aberdeen University showed the importance of executive function to adhering to healthy eating resolutions.
For instance, when volunteers regularly Body Beauty Slimming Coffee wrote down what they ate over a three day period, those shown in tests to have poor executive function ate less fruit and vegetables and more sugary snacks than they’d intended.
And when dieters were given the option to tuck into chocolate, those with poor executive function were more likely to give into temptation.
Dr Allan, who describes herself as having poor executive function, said: “A person with less efficient executive function is less likely to resist temptation and stick with what they had planned on any given day, than someone with excellent executive function.”